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Statins suppress cell-to-cell propagation of α-synuclein by lowering cholesterol

Abstract Cell-to-cell propagation of protein aggregates has been implicated in the progression of neurodegenerative diseases. However, the underlying mechanism and modulators of this process are not fully understood. Here, we screened a small-molecule library in a search for agents that suppress the...

Бүрэн тодорхойлолт

-д хадгалсан:
Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Joo-Ok Min, Hoang-Anh Ho, Wonjae Lee, Byung Chul Jung, Sung Jun Park, Seokjoong Kim, Seung-Jae Lee
Формат: Artigo
Хэл сонгох:Inglês
Хэвлэсэн: Nature Publishing Group 2023-07-01
Цуврал:Cell Death and Disease
Онлайн хандалт:https://doi.org/10.1038/s41419-023-05977-9
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