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Digging into Lipid Membrane Permeation for Cardiac Ion Channel Blocker d-Sotalol with All-Atom Simulations

Interactions of drug molecules with lipid membranes play crucial role in their accessibility of cellular targets and can be an important predictor of their therapeutic and safety profiles. Very little is known about spatial localization of various drugs in the lipid bilayers, their active form (ioni...

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Principais autores: Kevin R. DeMarco, Slava Bekker, Colleen E. Clancy, Sergei Y. Noskov, Igor Vorobyov
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2018-02-01
叢編:Frontiers in Pharmacology
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在線閱讀:http://journal.frontiersin.org/article/10.3389/fphar.2018.00026/full
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