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Repurposing Mercaptopurine Through Collateral Lethality to Treat Cancers with Somatic RB1–NUDT15 Loss

ABSTRACT Somatic retinoblastoma 1 (RB1) loss is prevalent across different cancer types and is enriched in treatment‐refractory tumors, such as castration‐resistant prostate cancer (CRPC) and small‐cell lung cancer, but cannot be considered as a direct druggable target. In this study, we revealed th...

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Principais autores: Tao Zhou, Huayun Yan, Dandan Yin, Yun Deng, Huancheng Fu, Zichen Zhao, Shuang Li, Xiaoxi Lu, Yiqi Deng, Hai‐Ning Chen, Wei‐Han Zhang, Yunying Shi, Yangjuan Bai, Bei Cai, Lanlan Wang, Zhaoqian Liu, Wei Zhang, Lili Jiang, Yang Shu, Bo Liu, Yan Zhang, Heng Xu
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2025-09-01
coleção:MedComm
Assuntos:
collateral lethality
copy number deletion
drug repurposing
mercaptopurine
NUDT15
RB1
Acesso em linha:https://doi.org/10.1002/mco2.70361
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