A defined method for differentiating human iPSCs into midbrain dopaminergic progenitors that safely restore motor deficits in Parkinson’s disease

BackgroundParkinson’s disease (PD) is a progressive neurodegenerative condition that primarily affects motor functions; it is caused by the loss of midbrain dopaminergic (mDA) neurons. The therapeutic effects of transplanting human-induced pluripotent stem cell (iPSC)-derived mDA neural progenitor c...

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Hlavní autoři:	Ryota Nakamura, Risa Nonaka, Genko Oyama, Takayuki Jo, Hikaru Kamo, Maierdanjiang Nuermaimaiti, Wado Akamatsu, Kei-ichi Ishikawa, Nobutaka Hattori
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-07-01
Edice:	Frontiers in Neuroscience
Témata:	Parkinson’s disease iPS cells regenerative medicine cell transplantation dopaminergic neurons
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fnins.2023.1202027/full
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