Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Familial Parkinson’s Disease Patients Display α-Synuclein Pathology and Abnormal Mitochondrial Morphology

Accumulation of α-synuclein (α-syn) into Lewy bodies (LBs) and mitochondrial abnormalities are the two cardinal pathobiological features of Parkinson’s disease (PD), which are associated with the loss of dopaminergic neurons. Although α-syn accumulates in many different cellular and mouse models, th...

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Principais autores:	Xiaojun Diao, Fei Wang, Andrea Becerra-Calixto, Claudio Soto, Abhisek Mukherjee
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2021-09-01
Series:	Cells
Assuntos:	Parkinson’s disease iPSC dopaminergic neurons α-synuclein aggregates Lewy bodies mitochondria
Acceso en liña:	https://www.mdpi.com/2073-4409/10/9/2402
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