Oxidative stress induced by sustained supraphysiological intrastriatal GDNF delivery is prevented by dose regulation

Despite its established neuroprotective effect on dopaminergic neurons and encouraging phase I results, intraputaminal GDNF administration failed to demonstrate significant clinical benefits in Parkinson’s disease patients. Different human GDNF doses were delivered in the striatum of rats with a pro...

पूर्ण विवरण

ग्रंथसूची विवरण

मुख्य लेखकों:	Marcelo Duarte Azevedo, Naika Prince, Marie Humbert-Claude, Virginia Mesa-Infante, Cheryl Jeanneret, Valentine Golzne, Kevin De Matos, Benjamin Boury Jamot, Fulvio Magara, Tomas Gonzalez-Hernandez, Liliane Tenenbaum
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Elsevier 2023-12-01
श्रृंखला:	Molecular Therapy: Methods & Clinical Development
विषय:	GDNF Parkinson’s disease 6-hydroxydopamine dopaminergic neurons AAV doxycycline
ऑनलाइन पहुंच:	http://www.sciencedirect.com/science/article/pii/S2329050123001390
टैग:	टैग जोड़ें कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!