Oxidative stress induced by sustained supraphysiological intrastriatal GDNF delivery is prevented by dose regulation

Despite its established neuroprotective effect on dopaminergic neurons and encouraging phase I results, intraputaminal GDNF administration failed to demonstrate significant clinical benefits in Parkinson’s disease patients. Different human GDNF doses were delivered in the striatum of rats with a pro...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Marcelo Duarte Azevedo, Naika Prince, Marie Humbert-Claude, Virginia Mesa-Infante, Cheryl Jeanneret, Valentine Golzne, Kevin De Matos, Benjamin Boury Jamot, Fulvio Magara, Tomas Gonzalez-Hernandez, Liliane Tenenbaum
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Elsevier 2023-12-01
Sarja:	Molecular Therapy: Methods & Clinical Development
Aiheet:	GDNF Parkinson’s disease 6-hydroxydopamine dopaminergic neurons AAV doxycycline
Linkit:	http://www.sciencedirect.com/science/article/pii/S2329050123001390
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