Ceramide-induced cleavage of GPR64 intracellular domain drives Ewing sarcoma
Summary: Ewing sarcoma is a cancer of bone and soft tissue in children and young adults primarily driven by the EWS-FLI1 fusion oncoprotein, which has been undruggable. Here, we report that Ewing sarcoma depends on secreted sphingomyelin phosphodiesterase 1 (SMPD1), a ceramide-generating enzyme, and...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2024-08-01
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| Col·lecció: | Cell Reports |
| Matèries: | |
| Accés en línia: | http://www.sciencedirect.com/science/article/pii/S221112472400826X |
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