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JNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis

Abstract Neutrophils cast neutrophil extracellular traps (NETs) to ensnare microbial pathogens. Nevertheless, the molecular rheostats that regulate NETosis in response to bacteria are not clearly established. We hypothesized that stress-activated protein kinase or c-Jun N-terminal Kinase (SAPK/JNK)...

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Autores principales: Meraj A. Khan, Armin Farahvash, David N. Douda, Johann-Christoph Licht, Hartmut Grasemann, Neil Sweezey, Nades Palaniyar
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Portfolio 2017-06-01
Colección:Scientific Reports
Acceso en línea:https://doi.org/10.1038/s41598-017-03257-z
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