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JNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis

Abstract Neutrophils cast neutrophil extracellular traps (NETs) to ensnare microbial pathogens. Nevertheless, the molecular rheostats that regulate NETosis in response to bacteria are not clearly established. We hypothesized that stress-activated protein kinase or c-Jun N-terminal Kinase (SAPK/JNK)...

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主要な著者: Meraj A. Khan, Armin Farahvash, David N. Douda, Johann-Christoph Licht, Hartmut Grasemann, Neil Sweezey, Nades Palaniyar
フォーマット: Artigo
言語:Inglês
出版事項: Nature Portfolio 2017-06-01
シリーズ:Scientific Reports
オンライン・アクセス:https://doi.org/10.1038/s41598-017-03257-z
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