Yin-Yang 1 and HBx protein activate HBV transcription by mediating the spatial interaction of cccDNA minichromosome with cellular chromosome 19p13.11

HBV cccDNA stably exists in the nuclei of infected cells as an episomal munichromosome which is responsible for viral persistence and failure of current antiviral treatments. However, the regulatory mechanism of cccDNA transcription by viral and host cellular factors is not well understood. In this...

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Autori principali:	Congle Shen, Xiaoyu Feng, Tianhao Mao, Danli Yang, Jun Zou, Xiaobin Zao, Qiang Deng, Xiangmei Chen, Fengmin Lu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis Group 2020-01-01
Serie:	Emerging Microbes and Infections
Soggetti:	HBV cccDNA HBV transcription regulation spatial interaction chromosome 19p13.11 YY1
Accesso online:	https://www.tandfonline.com/doi/10.1080/22221751.2020.1840311
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