Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole

Antimicrobial drug resistance is currently one of the most critical health issues. Pathogens resistant to last-resort antibiotics are increasing, and very few effective antibacterial agents have been introduced in recent years. The promising drug candidates are often discontinued in the primary stag...

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Detalhes bibliográficos

Principais autores:	Martin Juhás, Andrea Bachtíková, Daria Elżbieta Nawrot, Paulína Hatoková, Vinod Sukanth Kumar Pallabothula, Adéla Diepoltová, Ondřej Janďourek, Pavel Bárta, Klára Konečná, Pavla Paterová, Vít Šesták, Jan Zitko
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-05-01
Colecção:	Pharmaceuticals
Assuntos:	aminooxazole aminothiazole antimycobacterial activity docking molecular docking molecular dynamics
Acesso em linha:	https://www.mdpi.com/1424-8247/15/5/580
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