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Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole

Antimicrobial drug resistance is currently one of the most critical health issues. Pathogens resistant to last-resort antibiotics are increasing, and very few effective antibacterial agents have been introduced in recent years. The promising drug candidates are often discontinued in the primary stag...

Täydet tiedot

Tallennettuna:
Päätekijät: Martin Juhás, Andrea Bachtíková, Daria Elżbieta Nawrot, Paulína Hatoková, Vinod Sukanth Kumar Pallabothula, Adéla Diepoltová, Ondřej Janďourek, Pavel Bárta, Klára Konečná, Pavla Paterová, Vít Šesták, Jan Zitko
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI AG 2022-05-01
Sarja:Pharmaceuticals
Aiheet:
aminooxazole
aminothiazole
antimycobacterial activity
docking
molecular docking
molecular dynamics
Linkit:https://www.mdpi.com/1424-8247/15/5/580
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