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Amylovis-201 is a new dual-target ligand, acting as an anti-amyloidogenic compound and a potent agonist of the σ1 chaperone protein

The aggregation of Amyloid-β (Aβ) peptides is associated with neurodegeneration in Alzheimer's disease (AD). We previously identified novel naphtalene derivatives, including the lead compound Amylovis-201, able to form thermodynamically stable complexes with Aβ species, peptides and fibrils. As the...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Laura García-Pupo, Lucie Crouzier, Alberto Bencomo-Martínez, Johann Meunier, Axelle Morilleau, Benjamin Delprat, Marquiza Sablón Carrazana, Roberto Menéndez Soto del Valle, Tangui Maurice, Chryslaine Rodríguez-Tanty
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2024-10-01
Schriftenreihe:Acta Pharmaceutica Sinica B
Schlagworte:
Alzheimer's disease
Amyloid-β aggregation
Neuroprotection
σ1 receptor
Drug discovery
Molecular modelisation
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2211383524002442
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