Amylovis-201 is a new dual-target ligand, acting as an anti-amyloidogenic compound and a potent agonist of the σ1 chaperone protein

The aggregation of Amyloid-β (Aβ) peptides is associated with neurodegeneration in Alzheimer's disease (AD). We previously identified novel naphtalene derivatives, including the lead compound Amylovis-201, able to form thermodynamically stable complexes with Aβ species, peptides and fibrils. As the...

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Autores principales:	Laura García-Pupo, Lucie Crouzier, Alberto Bencomo-Martínez, Johann Meunier, Axelle Morilleau, Benjamin Delprat, Marquiza Sablón Carrazana, Roberto Menéndez Soto del Valle, Tangui Maurice, Chryslaine Rodríguez-Tanty
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2024-10-01
Colección:	Acta Pharmaceutica Sinica B
Materias:	Alzheimer's disease Amyloid-β aggregation Neuroprotection σ1 receptor Drug discovery Molecular modelisation
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2211383524002442
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