Dual-antigen recognition iPSC-derived CAR-T cells for B-cell malignancies: establishment of a COVID-19 vaccine synergy strategy

IntroductionCD19-directed chimeric antigen receptor (CD19-CAR) T-cell therapy has markedly improved outcomes in relapsed and refractory B-cell malignancies, but its efficacy remains limited by insufficient in vivo persistence and functional exhaustion. We have generated functionally rejuvenated T-ce...

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Autores principales:	Norihide Izumi, Yoshiki Furukawa, Shintaro Kinoshita, Midori Ishii, Ayaka Goto, Hajime Yasuda, Jun Ando, Hiromitsu Nakauchi, Miki Ando
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2026-02-01
Colección:	Frontiers in Cell and Developmental Biology
Materias:	CAR-T iPSC-derived T-cells SARS-CoV-2 TCR restimulation vaccine synergy
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fcell.2026.1772146/full
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