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Dual-antigen recognition iPSC-derived CAR-T cells for B-cell malignancies: establishment of a COVID-19 vaccine synergy strategy

IntroductionCD19-directed chimeric antigen receptor (CD19-CAR) T-cell therapy has markedly improved outcomes in relapsed and refractory B-cell malignancies, but its efficacy remains limited by insufficient in vivo persistence and functional exhaustion. We have generated functionally rejuvenated T-ce...

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Tallennettuna:
Päätekijät: Norihide Izumi, Yoshiki Furukawa, Shintaro Kinoshita, Midori Ishii, Ayaka Goto, Hajime Yasuda, Jun Ando, Hiromitsu Nakauchi, Miki Ando
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2026-02-01
Sarja:Frontiers in Cell and Developmental Biology
Aiheet:
CAR-T
iPSC-derived T-cells
SARS-CoV-2
TCR restimulation
vaccine synergy
Linkit:https://www.frontiersin.org/articles/10.3389/fcell.2026.1772146/full
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