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Peptide aptamer sP10 targeting NPM1 attenuates liver fibrosis and hepatocellular carcinoma

Abstract Objective Liver fibrosis and hepatocellular carcinoma (HCC) are interrelated diseases with high global mortality rates and limited therapeutic options. This study aimed to develop a dual-targeting therapeutic agent against both fibrogenesis and hepatocarcinogenesis by targeting nucleophosmi...

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Principais autores: Xian Feng, Hai-Bin Pang, Yong-Gui Wei, Dong-Hui Xu, Xin-Le Zhu, Dai Cao, Yang Yu, Ya-Fen Chen, Ling Yang, Yu-Jun Zhang, Xiao-Ling Deng, Li-Ping Bai, Kuan-Can Liu, Song-Lin Shi
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-04-01
Serier:Journal of Translational Medicine
Fag:
Peptide aptamer
Nucleophosmin
Liver fibrosis
Hepatocellular carcinoma
Online adgang:https://doi.org/10.1186/s12967-026-08144-8
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