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Thread-structural microneedles loaded with engineered exosomes for annulus fibrosus repair by regulating mitophagy recovery and extracellular matrix homeostasis

Low back pain is among the most grave public health concerns worldwide and the major clinical manifestation of intervertebral disc degeneration (IVDD). The destruction of annulus fibrosus (AF) is the primary cause of IVDD. A sustainable and stable treatment system for IVDD is lacking because of the...

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Principais autores: Shaojun Hu, Meng Zhu, Hongyuan Xing, Yucheng Xue, Jun Li, Zhan Wang, Zhou Zhu, Miaojie Fang, Zilong Li, Jianbin Xu, Yong He, Ning Zhang
Format: Artigo
Sprog:Inglês
Udgivet: KeAi Communications Co., Ltd. 2024-07-01
Serier:Bioactive Materials
Fag:
Intervertebral disc degeneration
Microneedle
Exosomes
Annulus fibrosus
Mitophagy
Online adgang:http://www.sciencedirect.com/science/article/pii/S2452199X24000872
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