Exploring drug resistance via intercellular crosstalk using spatial transcriptomics in high-grade serous ovarian carcinoma

Abstract Poly(ADP-ribose) polymerase inhibitors (PARPis) have improved the prognosis of patients with high-grade serous ovarian carcinoma (HGSOC). However, PARPis are not effective for all HGSOC patients. Spatial transcriptomics is a powerful tool for characterizing the tumor microenvironment. We us...

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Autors principals:	Hironori Suzuki, Kosuke Yoshida, Akira Yokoi, Kazuhiro Suzuki, Yuta Hirano, Masami Kitagawa, Eri Asano-Inami, Masato Yoshihara, Yukari Nagao, Satoshi Tamauchi, Nobuhisa Yoshikawa, Hiroaki Kajiyama, Yusuke Yamamoto
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-11-01
Col·lecció:	npj Precision Oncology
Accés en línia:	https://doi.org/10.1038/s41698-025-01122-1
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