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Latent KSHV Infected Endothelial Cells Are Glutamine Addicted and Require Glutaminolysis for Survival.

Kaposi's Sarcoma-associated Herpesvirus (KSHV) is the etiologic agent of Kaposi's Sarcoma (KS). KSHV establishes a predominantly latent infection in the main KS tumor cell type, the spindle cell, which is of endothelial cell origin. KSHV requires the induction of multiple metabolic pathways, includi...

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Autori principali: Erica L Sanchez, Patrick A Carroll, Angel B Thalhofer, Michael Lagunoff
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2015-07-01
Serie:PLoS Pathogens
Accesso online:http://europepmc.org/articles/PMC4510438?pdf=render
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