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Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library

Although antibiotic treatment for Lyme disease is effective in the majority of cases, especially during the early phase of the disease, a minority of patients suffer from post-treatment Lyme disease syndrome (PTLDS). It is unclear what mechanisms drive this problem, and although slow or ineffective...

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Main Authors: Jie Feng, Ting Wang, Wanliang Shi, Shuo Zhang, David Sullivan, Paul G Auwaerter, Ying Zhang
Format: Artigo
Language:Inglês
Published: Taylor & Francis Group 2014-01-01
Series:Emerging Microbes and Infections
Subjects:
Borrelia burgdorferi
drug discovery
FDA approved drug library
persisters
SYBR Green I
Online Access:https://www.tandfonline.com/doi/10.1038/emi.2014.53
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