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A Single Mutation Increases the Thermostability and Activity of <i>Aspergillus terreus</i> Amine Transaminase

Enhancing the thermostability of (<i>R</i>)-selective amine transaminases (AT-ATA) will expand its application in the asymmetric synthesis of chiral amines. In this study, mutual information and coevolution networks of ATAs were analyzed by the Mutual Information Server to Infer Coevolution (MISTIC)...

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Principais autores: Wan-Li Zhu, Sheng Hu, Chang-Jiang Lv, Wei-Rui Zhao, Hong-Peng Wang, Jia-Qi Mei, Le-He Mei, Jun Huang
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2019-03-01
Serier:Molecules
Fag:
amine transaminase
mutual information (MI)
saturation mutagenesis
differential scanning fluorimetry (DSF)
thermostability
Online adgang:https://www.mdpi.com/1420-3049/24/7/1194
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