Squalene-Based Nano-Assemblies Improve the Pro-Autophagic Activity of Trehalose

The disaccharide trehalose is a well-established autophagy inducer, but its therapeutic application is severely hampered by its low potency and poor pharmacokinetic profile. Thus, we targeted the rational design and synthesis of trehalose-based small molecules and nano objects to overcome such issue...

Disgrifiad llawn

Manylion Llyfryddiaeth

Prif Awduron:	Giulia Frapporti, Eleonora Colombo, Hazem Ahmed, Giulia Assoni, Laura Polito, Pietro Randazzo, Daniela Arosio, Pierfausto Seneci, Giovanni Piccoli
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	MDPI AG 2022-04-01
Cyfres:	Pharmaceutics
Pynciau:	autophagy inducers trehalose squalene conjugates nanoassemblies reduction-labile linkers cancer
Mynediad Ar-lein:	https://www.mdpi.com/1999-4923/14/4/862
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!