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Squalene-Based Nano-Assemblies Improve the Pro-Autophagic Activity of Trehalose

The disaccharide trehalose is a well-established autophagy inducer, but its therapeutic application is severely hampered by its low potency and poor pharmacokinetic profile. Thus, we targeted the rational design and synthesis of trehalose-based small molecules and nano objects to overcome such issue...

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Principais autores: Giulia Frapporti, Eleonora Colombo, Hazem Ahmed, Giulia Assoni, Laura Polito, Pietro Randazzo, Daniela Arosio, Pierfausto Seneci, Giovanni Piccoli
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-04-01
Serier:Pharmaceutics
Fag:
autophagy inducers
trehalose
squalene conjugates
nanoassemblies
reduction-labile linkers
cancer
Online adgang:https://www.mdpi.com/1999-4923/14/4/862
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