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Navitoclax acts synergistically with irradiation to induce apoptosis in preclinical models of H3K27M-altered diffuse midline glioma

Abstract Diffuse midline gliomas (DMGs) with histone H3K27M mutations represent a devastating paediatric brain cancer characterised by abysmal prognosis and limited treatment options. The only approved treatment is radiotherapy (RT), but most of the tumours relapse with fatal consequences. The effec...

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Principais autores: Ashley Vardon, Scott Haston, Hiba Hamdi, Grace Cooksley, Romain Guiho, Diana Carvalho, Rebecca Carter, Jessica Katherine Rowena Boult, Daniel Gharai, Ielyaas Cloete, James Grey, John Apps, Daohong Zhou, Guangrong Zheng, Ramón Martínez-Máñez, Mark Francis Lythgoe, Laura Kate Donovan, Angel Montero Carcaboso, Owen Williams, Ying Hong, Paula Alexandre, Jesus Gil, Jamie Adam Dean, David Michod, Chris Jones, Darren Hargrave, Juan-Pedro Martinez-Barbera
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-12-01
Serier:Scientific Reports
Fag:
H327M-altered diffuse midline glioma
Cellular senescence
Senolytic therapy
BH3-mimetics
Bcl-xL
Online adgang:https://doi.org/10.1038/s41598-025-32676-6
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