Q11, a CYP2E1 inhibitor, exerts anti-hepatocellular carcinoma effect by inhibiting M2 macrophage polarization

Abstract Despite significant advancements in cancer immunotherapy, many patients continue to respond poorly. Novel therapeutic strategies and drugs are urgently needed. Here, we found that CYP2E1 is upregulated in M2 macrophages. The CYP2E1 inhibitor, Q11, could inhibit M2 macrophage polarization, w...

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Bibliografiske detaljer

Principais autores:	Cunzhen Zhang, Yan Fang, Mengxue Guo, Liming Tang, Yurong Xing, Jun Zhou, Yuanyuan Guo, Yuhan Gu, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao
Format:	Artigo
Sprog:	Inglês
Udgivet:	Springer 2024-12-01
Serier:	Cancer Immunology, Immunotherapy
Fag:	Hepatocellular carcinoma CYP2E1 Inhibitor M2 macrophage Metabolites
Online adgang:	https://doi.org/10.1007/s00262-024-03912-1
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