Expression of a PCSK9 Gain-of-Function Mutation in C57BL/6J Mice to Facilitate Angiotensin II-Induced AAAs

Angiotensin II (AngII) infusion in mice has been used widely to investigate mechanisms of abdominal aortic aneurysms (AAAs). To achieve a high incidence of AngII-induced AAAs, mice should be hypercholesterolemic. Therefore, either low-density lipoprotein receptor (LDLR) or apolipoprotein E deficienc...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Hisashi Sawada, Alan Daugherty, Hong S. Lu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2022-06-01
Schriftenreihe:	Biomolecules
Schlagworte:	PCSK9 hypercholesterolemia adeno-associated virus angiotensin aortic aneurysm mouse
Online-Zugang:	https://www.mdpi.com/2218-273X/12/7/915
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