Expression of a PCSK9 Gain-of-Function Mutation in C57BL/6J Mice to Facilitate Angiotensin II-Induced AAAs

Angiotensin II (AngII) infusion in mice has been used widely to investigate mechanisms of abdominal aortic aneurysms (AAAs). To achieve a high incidence of AngII-induced AAAs, mice should be hypercholesterolemic. Therefore, either low-density lipoprotein receptor (LDLR) or apolipoprotein E deficienc...

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Principais autores:	Hisashi Sawada, Alan Daugherty, Hong S. Lu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-06-01
coleção:	Biomolecules
Assuntos:	PCSK9 hypercholesterolemia adeno-associated virus angiotensin aortic aneurysm mouse
Acesso em linha:	https://www.mdpi.com/2218-273X/12/7/915
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