Binding-driven forward tearing protospacer activated CRISPR-Cas12a system and applications for microRNA detection

Abstract CRISPR-Cas12a system, characterized by its precise sequence recognition and cleavage activity, has emerged as a powerful and programmable tool for molecular diagnostics. However, current CRISPR-Cas12a-based nucleic acid detection methods, particularly microRNA (miRNA) detection, necessitate...

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Principais autores:	Lina Zhao, Xiangyu Deng, Yuqing Li, Qing Zhao, Lizhu Xiao, Jianjiang Xue, Anyi Chen, Wei Cheng, Min Zhao
格式:	Artigo
语言:	Inglês
出版:	BMC 2024-11-01
丛编:	Journal of Nanobiotechnology
主题:	CRISPR-Cas12a MicroRNA Hairpin DNA Biosensing
在线阅读:	https://doi.org/10.1186/s12951-024-02915-5
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