The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2
Abstract Zinc levels are high in pancreatic β-cells, and zinc is involved in the synthesis, processing and secretion of insulin in these cells. However, precisely how cellular zinc homeostasis is regulated in pancreatic β-cells is poorly understood. By screening the expression of 14 Slc39a metal imp...
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| Główni autorzy: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Oxford University Press
2018-10-01
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| Seria: | Protein & Cell |
| Hasła przedmiotowe: | |
| Dostęp online: | http://link.springer.com/article/10.1007/s13238-018-0580-1 |
| Etykiety: |
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