Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity

Conversion of fibroblasts into functional cardiomyocytes represents a potential means of restoring cardiac function after myocardial infarction, but so far this process remains inefficient and little is known about its molecular mechanisms. Here we show that DAPT, a classical Notch inhibitor, enhanc...

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Autors principals:	Maria Abad, Hisayuki Hashimoto, Huanyu Zhou, Maria Gabriela Morales, Beibei Chen, Rhonda Bassel-Duby, Eric N. Olson
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2017-03-01
Col·lecció:	Stem Cell Reports
Matèries:	direct cellular reprogramming cell-fate conversion transdifferentiation cardiomyocytes Notch signaling DAPT heart regeneration regenerative medicine
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2213671117300413
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