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Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity

Conversion of fibroblasts into functional cardiomyocytes represents a potential means of restoring cardiac function after myocardial infarction, but so far this process remains inefficient and little is known about its molecular mechanisms. Here we show that DAPT, a classical Notch inhibitor, enhanc...

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Principais autores: Maria Abad, Hisayuki Hashimoto, Huanyu Zhou, Maria Gabriela Morales, Beibei Chen, Rhonda Bassel-Duby, Eric N. Olson
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017-03-01
Serier:Stem Cell Reports
Fag:
direct cellular reprogramming
cell-fate conversion
transdifferentiation
cardiomyocytes
Notch signaling
DAPT
heart regeneration
regenerative medicine
Online adgang:http://www.sciencedirect.com/science/article/pii/S2213671117300413
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