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What AlphaFold tells us about cohesin’s retention on and release from chromosomes

Cohesin is a trimeric complex containing a pair of SMC proteins (Smc1 and Smc3) whose ATPase domains at the end of long coiled coils (CC) are interconnected by Scc1. During interphase, it organizes chromosomal DNA topology by extruding loops in a manner dependent on Scc1’s association with two large...

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Autors principals: Kim A Nasmyth, Byung-Gil Lee, Maurici Brunet Roig, Jan Löwe
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications Ltd 2023-11-01
Col·lecció:eLife
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Accés en línia:https://elifesciences.org/articles/88656
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