Napabucasin overcomes cisplatin resistance in ovarian germ cell tumor-derived cell line by inhibiting cancer stemness

Abstract Background Cisplatin resistance of ovarian yolk sac tumors (oYST) is a clinical challenge due to dismal patient prognosis, even though the disease is extremely rare. We investigated potential association between cisplatin resistance and cancer stem cell (CSC) markers in chemoresistant oYST...

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Detalhes bibliográficos

Principais autores:	Silvia Schmidtova, Lambert C. J. Dorssers, Katarina Kalavska, Ad J. M. Gillis, J. Wolter Oosterhuis, Hans Stoop, Svetlana Miklikova, Zuzana Kozovska, Monika Burikova, Katarina Gercakova, Erika Durinikova, Michal Chovanec, Michal Mego, Lucia Kucerova, Leendert H. J. Looijenga
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-08-01
coleção:	Cancer Cell International
Assuntos:	Yolk sac tumor Cisplatin Aldehyde dehydrogenase Cancer stem cells
Acesso em linha:	http://link.springer.com/article/10.1186/s12935-020-01458-7
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