Cognitive impairment and biomarkers of gut microbial translocation in testicular germ cell tumor survivors

BackgroundSurvivors of testicular germ cell tumors (GCT) may suffer from late cognitive impairment. We hypothesized that disruption of intestinal barrier during chemotherapy and/or radiotherapy may be a contributing factor of cognitive dysfunction within the gut-blood-brain axis.MethodsGCT survivors...

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Hauptverfasser:	Michal Chovanec, Katarina Kalavska, Jana Obertova, Patrik Palacka, Katarina Rejlekova, Zuzana Sycova-Mila, Zuzana Orszaghova, Peter Lesko, Valentina De Angelis, Lucia Vasilkova, Daniela Svetlovska, Beata Mladosievicova, Jozef Mardiak, Michal Pastorek, Barbora Vlkova, Peter Celec, Michal Mego
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2023-03-01
Schriftenreihe:	Frontiers in Oncology
Schlagworte:	cognitive impairment testicular germ cell tumor (GCT) biomarker gut microbial translocation late toxicity mechanism
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1146032/full
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