Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors
The enzyme geranylgeranyl diphosphate synthase (GGDPS) catalyzes the synthesis of the 20-carbon isoprenoid geranylgeranyl diphosphate (GGPP). GGPP is the isoprenoid donor for protein geranylgeranylation reactions catalyzed by the enzymes geranylgeranyl transferase (GGTase) I and II. Inhibitors of GG...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
MDPI AG
2017-05-01
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| Series: | Molecules |
| Assuntos: | |
| Acceso en liña: | http://www.mdpi.com/1420-3049/22/6/886 |
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