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GSK2606414 attenuates PERK/p-eIF2α/ATF4/CHOP axis and augments mitochondrial function to mitigate high glucose induced neurotoxicity in N2A cells

Neuronal dysfunction and subsequent apoptosis under high glucose conditions during diabetes contribute majorly to the manifestation of diabetic peripheral neuropathy (DPN). PERK (protein kinase RNA (PKR)-like ER kinase) one among the three canonical arms of unfolded protein response (UPR), is believ...

Deskribapen osoa

Gorde:
Egile Nagusiak: Chayanika Gundu, Vijay Kumar Arruri, Bhoomika Sherkhane, Dharmendra Kumar Khatri, Shashi Bala Singh
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2022-01-01
Saila:Current Research in Pharmacology and Drug Discovery
Gaiak:
GSK2606414
High glucose
PERK
ER stress
Mitochondrial function
Sarrera elektronikoa:http://www.sciencedirect.com/science/article/pii/S2590257122000074
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