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To die or not to die: Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 (RIPK1) function

Complex posttranslational modifications determine the effects of receptor-interacting protein kinase-1 (RIPK1) on cell survival and death. Studies from us and others have revealed a p38MAPK/MK2-dependent checkpoint in RIPK1 signaling. MAPKAP kinase 2 (MK2) phosphorylates RIPK1 to suppress RIPK1-medi...

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Autori principali: Manoj B. Menon, Julia Gropengießer, Klaus Ruckdeschel, Matthias Gaestel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2018-01-01
Serie:Molecular & Cellular Oncology
Soggetti:
ripk1
mk2
cell death
signal transduction
phosphorylation
Accesso online:http://dx.doi.org/10.1080/23723556.2017.1396389
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