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RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice

RIPK3 mediates cell death and regulates inflammatory responses. Although genetic studies have suggested that RIPK3-MLKL-mediated necroptosis leads to embryonic lethality in Fadd or Caspase-8-deficient mice, the exact mechanisms are not fully understood. Here, we generated Ripk3 mutant mice by alteri...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Qun Zhao, XianJun Yu, HaiWei Zhang, YongBo Liu, XiXi Zhang, XiaoXia Wu, Qun Xie, Ming Li, Hao Ying, Haibing Zhang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017-04-01
Schriftenreihe:Cell Reports
Schlagworte:
RIPK3
Fadd
kinase activity
necroptosis
embryogenesis
inflammation
cell death
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2211124717304862
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