Clinicopathological features of breast cancer in Ukrainian women with BRCA1 c.181T>G (p.Cys61Gly) variant: a case series

IntroductionBRCA1 c.181T>G (p.Cys61Gly) is a pathogenic founder genetic variant prevalent in Central and Eastern Europe. The data on its clinicopathological manifestations in Ukrainian patients remain limited.AimThis study aimed to characterize clinical presentation, tumor biology, and family his...

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Principais autores:	Nataliya Kitsera, Yaroslav Shparyk, Orest Tril, Ihor Protsko, Ivanna Duda, Olha Oleksyak, Andrii Hrynkiv, Irena Dovhanyk, Iryna Hrytsai, Iryna Tril, Halyna Makukh, Alina Kruhlykova, Denys Kozakov, Sofiia Livshun, Nazarii Kobyliak, Solomiia Sobechko, Myroslava Oliyarnyk, Oksana Sulaieva
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-06-01
coleção:	Frontiers in Endocrinology
Assuntos:	BRCA1 breast cancer c.181T>G variant family history germline variant tumor biology
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fendo.2026.1859939/full
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