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Liposomal UHRF1 siRNA shows lung fibrosis treatment potential through regulation of fibroblast activation

Pulmonary fibrosis is a chronic and progressive interstitial lung disease associated with the decay of pulmonary function, which leads to a fatal outcome. As an essential epigenetic regulator of DNA methylation, the involvement of ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) in fi...

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Bibliografske podrobnosti
Principais autores: Demin Cheng, Yue Wang, Ziwei Li, Haojie Xiong, Wenqing Sun, Sichuan Xi, Siyun Zhou, Yi Liu, Chunhui Ni
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical investigation 2022-11-01
Serija:JCI Insight
Teme:
Online dostop:https://doi.org/10.1172/jci.insight.162831
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