E-Cadherin Regulates HIF1-α In Vitro in Induced 3D Spheroid Models of Human Breast Cancer Through Both mTOR and Notch1 Signaling

<b>Background</b>: Both spontaneous and induced 3D spheroid models are among many in vitro models that recapitulate aspects of in vivo cancers. Although numerous studies have described the spatiotemporal relevance of these 3D models, there has been a paucity of studies investigating the signaling pa...

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Detalhes bibliográficos

Principais autores:	Yin Ye, Dollada Srisai, Sanford H. Barsky
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-11-01
Colecção:	Biomedicines
Assuntos:	3D spheroidgenesis induced spheroidgenesis spontaneous spheroidgenesis HIF-1α PI3K/AKT/mTOR signaling Notch1 signaling
Acesso em linha:	https://www.mdpi.com/2227-9059/13/12/2890
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