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TCR-engineered T cells meet new challenges to treat solid tumors: choice of antigen, T cell fitness and sensitisation of tumor milieu (review)

Adoptive transfer of T cells gene-engineered with antigen-specific T cell receptors (TCRs) has proven its feasibility and therapeutic potential in the treatment of malignant tumors. To ensure further clinical development of TCR gene therapy, it is necessary to target immunogenic epitopes that are re...

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Principais autores: Andre eKunert, Trudy eStraetemans, Coen eGovers, Cor eLamers, Ron eMathijssen, Stefan eSleijfer, Reno eDebets
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2013-11-01
Serier:Frontiers in Immunology
Fag:
Antigens
T cells
solid tumors
T cell differentiation
TCR Affinity
Inhibitory milieu
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00363/full
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