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Augmented myeloablative conditioning with olaparib in allogeneic hematopoietic stem cell transplantation for relapsed/refractory RUNX1::RUNX1T1-positive acute myeloid leukemia

BackgroundRelapsed/refractory RUNX1::RUNX1T1-positive acute myeloid leukemia remains a therapeutic challenge due to high relapse rates post-allogeneic hematopoietic stem cell transplantation. Preclinical evidence suggests that RUNX1::RUNX1T1 fusion proteins sensitize cells to poly ADP-ribose polymer...

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Main Authors: Song Xue, Wei Ma, Man Chen, Hui-peng Sun, Xing-yu Cao
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2026-03-01
Series:Frontiers in Oncology
Subjects:
allogeneic hematopoietic stem cell transplantation
conditioning regimen
olaparib
PARP inhibitor
relapse
RUNX1::RUNX1T1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2026.1608899/full
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