RIG-1-Like Receptor Activation Synergizes With Intratumoral Alpha Radiation to Induce Pancreatic Tumor Rejection, Triple-Negative Breast Metastases Clearance, and Antitumor Immune Memory in Mice

Diffusing alpha-emitting radiation therapy (DaRT) employs intratumoral Ra-224-coated seeds that efficiently destroy solid tumors by slowly releasing alpha-emitting atoms inside the tumor. In immunogenic tumor models, DaRT was shown to activate systemic antitumor immunity. Agonists of the membrane-bo...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Vered Domankevich, Margalit Efrati, Michael Schmidt, Eran Glikson, Fairuz Mansour, Amit Shai, Adi Cohen, Yael Zilberstein, Elad Flaisher, Razvan Galalae, Itzhak Kelson, Yona Keisari
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2020-07-01
Schriftenreihe:	Frontiers in Oncology
Schlagworte:	PolyIC polyethylenimine decitabine radiotherapy immunotherapy alpha radiation
Online-Zugang:	https://www.frontiersin.org/article/10.3389/fonc.2020.00990/full
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