RIG-1-Like Receptor Activation Synergizes With Intratumoral Alpha Radiation to Induce Pancreatic Tumor Rejection, Triple-Negative Breast Metastases Clearance, and Antitumor Immune Memory in Mice

Diffusing alpha-emitting radiation therapy (DaRT) employs intratumoral Ra-224-coated seeds that efficiently destroy solid tumors by slowly releasing alpha-emitting atoms inside the tumor. In immunogenic tumor models, DaRT was shown to activate systemic antitumor immunity. Agonists of the membrane-bo...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Vered Domankevich, Margalit Efrati, Michael Schmidt, Eran Glikson, Fairuz Mansour, Amit Shai, Adi Cohen, Yael Zilberstein, Elad Flaisher, Razvan Galalae, Itzhak Kelson, Yona Keisari
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2020-07-01
Edice:	Frontiers in Oncology
Témata:	PolyIC polyethylenimine decitabine radiotherapy immunotherapy alpha radiation
On-line přístup:	https://www.frontiersin.org/article/10.3389/fonc.2020.00990/full
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!