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Inhibiting microglia exacerbates the early effects of cuprizone in males in a rat model of multiple sclerosis, with no effect in females

Hyper-activity of the brain’s innate immune cells, microglia, is a hallmark of multiple sclerosis (MS). However, it is not clear whether this involvement of microglia is beneficial or detrimental or whether manipulating microglial activity may be therapeutic. We investigated if inhibiting microglial...

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Hlavní autoři: Soniya Xavier, Simin Younesi, Luba Sominsky, Sarah J. Spencer
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2023-09-01
Edice:Frontiers in Neurology
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On-line přístup:https://www.frontiersin.org/articles/10.3389/fneur.2023.989132/full
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