Divergent effects of itaconate isomers on Coxiella burnetii growth in macrophages and in axenic culture

Aconitate decarboxylase-1 (ACOD1) is expressed by activated macrophages and generates itaconate that exerts anti-microbial and immunoregulatory effects. ACOD1-itaconate is essential for macrophage-mediated control of the intracellular pathogen Coxiella (C.) burnetii, which causes Q fever. Two isomer...

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Detalhes bibliográficos

Principais autores:	Md Nur A Alam Siddique, Fabian Kellermeier, Martha Ölke, Mingming Zhao, Konrad Büssow, Peter J. Oefner, Anja Lührmann, Katja Dettmer, Roland Lang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-08-01
coleção:	Frontiers in Immunology
Assuntos:	ACOD1 IRG1 itaconate mesaconate citraconate uptake
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1427457/full
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