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ACOD1, rather than itaconate, facilitates p62‐mediated activation of Nrf2 in microglia post spinal cord contusion

Abstract Background Spinal cord injury (SCI)‐induced neuroinflammation and oxidative stress (OS) are crucial events causing neurological dysfunction. Aconitate decarboxylase 1 (ACOD1) and its metabolite itaconate (Ita) inhibit inflammation and OS by promoting alkylation of Keap1 to induce Nrf2 expre...

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Principais autores: Zhanyang Qian, Mingjie Xia, Tianyu Zhao, You Li, Guangshen Li, Yanan Zhang, Haijun Li, Lei Yang
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2024-04-01
Serier:Clinical and Translational Medicine
Fag:
aconitate decarboxylase 1
itaconate
neuroinflammation
Nrf2
p62
spinal cord injury
Online adgang:https://doi.org/10.1002/ctm2.1661
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